Scientific Studies Shows Positive Effects of Nicotinamide Mononucleotide (NMN)

Posted by MISC CREW on on Oct 26th 2021

When inside the human body, NMN contributes to the production of NAD+, which offers necessary energy to cells and is assumed to be essential for healthy aging. 

NAD+ is also important in the activation of proteins that keep our DNA intact. Because NMN plays such an important role in so many cellular processes, it is possible advantages stretch to almost all body systems. 

A few of the of the more well-known examples are listed below.

Vascular health and blood flow are improved.

Our skeletal muscles are responsible for movement, stability, and strength. These muscles must absorb considerable quantities of key energy particles, such as glucose and fatty acids, in order to stay powerful and in excellent condition. Because NAD+ is needed to metabolize these particles, our muscle fibers ensure a constant supply of its constituents, such as NMN.

NMN has been shown in mouse studies to protect against a variety of aging-related health declines, including blood vessel stiffness, oxidative stress, our cells' capacity to divide, or even modifications in how involved our genetic traits are, a process known as gene expression. [1]

Muscle Endurance and Strength are Improved

Long-term NMN administration to mice resulted in improved energy metabolism with no obvious side effects, according to research. As we gets older, the health of our muscles becomes highly significant, with our own supply of NAD+ diminishes..

Helps to Prevent Heart Disease

At the very least, your muscle fibers get to rest. Not only can your heart not rest, but it can't even slow down without having caused serious problems. As a result, the heart's energy requirements are enormous. And in order to keep going, it must produce as much NAD+ as possible. This is why cardiac cells require a constant supply of NMN.

Reduces Obesity Risk

Obesity is related to a variety of unhealthy conditions and can be difficult to treat. Obesity and related conditions such as diabetes and metabolic syndrome do not have a simple cure. While lifestyle changes such as consistent exercise and a healthy diet are critical, every little bit helps.

In mouse studies, NMN has been shown to mimic aspects of calorie restriction (CR). CR was shown to provide substantial advantages to aging and health, but it is a difficult regime to maintain over time. It would be indisputably advantageous to mimic its advantages without having to adhere to such an unhealthy diet.[2]

Improves DNA Repair Maintenance

The NAD+ produced by NMN activates a family of proteins known as sirtuins. Sirtuins, also known as the "protectors of our health," play an important role in maintaining DNA integrity. When our cells are dividing, the DNA at the end points of our chromosomes gets a little shorter. This, at some point, begins to harm our genes. Sirtuins sluggish this process by stabilizing the end bits, which are referred to scientifically as telomeres. Sirtuins, on the other hand, rely on NAD+ to function. According to recent research, feeding mice NMN activated sirtuins, resulting in more steady telomeres.

Boosts Mitochondrial Function

We would not be able to survive without our mitochondria. These distinct cellular structures are referred to as the cell's powerhouses. They convert molecules from our food into energy that our cells can use. This process relies heavily on NAD+. Indeed, mitochondrial abnormalities caused by NAD+ deficiency may have an effect on neurological disorders such as Alzheimer's. NMN supplementation has been shown to improve some mitochondrial dysfunctions in mice research.

Furthermore, nicotinamide riboside chloride may have the following advantages:

1. Nicotinamide riboside chloride may help with weight loss: Nicotinamide riboside chloride increased the metabolic rate of mice.

2. Cancer risk may be reduced due to nicotinamide riboside chloride because High NAD+ levels help protect against Mutations and oxidative stress, both of which are linked to cancer progression.[3]


1.Poddar, S. K., Sifat, A. E., Haque, S., Nahid, N. A., Chowdhury, S., & Mehedi, I. (2019). Nicotinamide mononucleotide: exploration of diverse therapeutic applications of a potential molecule. Biomolecules, 9(1), 34.

2.Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., ... & Klein, S. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 372(6547), 1224-1229.

3.Roos, J., Zinngrebe, J., & Fischer-Posovszky, P. (2021). Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance. Signal Transduction and Targeted Therapy, 6(1), 1-2.